ADAM9 is present at endothelial cell - cell junctions and regulates monocyte – endothelial transmigration

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ADAM9 is present at endothelial cell - cell junctions and regulates monocyte – endothelial transmigration

We have found that A Disintegrin And Metalloproteinase-9 (ADAM9) localises to cell-cell junctions with VE-Cadherin in confluent endothelial monolayers. Co-cultures of cells separately transfected with ADAM9-EGFP or ADAM9-HA showed expression is required in two adjacent cells for localisation to cell-cell junctions suggesting the ADAM9 ectodomain may self-associate. A direct interaction between ...

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Endothelial-dependent Mechanisms Regulate Leukocyte Transmigration: A Process Involving the Proteasome and Disruption of the Vascular Endothelial–Cadherin Complex at Endothelial Cell-to-Cell Junctions

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ژورنال

عنوان ژورنال: Biochemical and Biophysical Research Communications

سال: 2017

ISSN: 0006-291X

DOI: 10.1016/j.bbrc.2017.09.089